Naltrexone is in a class of medication known as opioid receptor antagonist. It works by blocking the effects of narcotic drugs and is used to prevent substance abuse in people who have been addicted to alcohol or opioid pain medications. In addition to the antagonist effect on opioid receptors, naltrexone simultaneously has an antagonist effect on non-opioid receptors. It is via the non-opioid antagonist path that Naltrexone at low dose (LDN) is thought to exert its anti-inflammatory effects. Basic science evidence supports that concept by showing that low- and high-dose opioid antagonists have quite different impacts on the physiologic system. As a rule of thumb, low dose would range from 0.5 to 4.5 mg daily.
Naltrexone is almost completely absorbed (96%), but its oral bioavailability ranges between 5% and 40% due to first-pass metabolism
Use of low dose naltrexone (LDN) for inflammatory diseases, fibromyalgia, neurological conditions, cancer and mood disorders
Low doses of naltrexone have been shown to reduce symptom severity in
Use of LDN for Weight Loss
LDN can help balance the emotional hormones in your body (such as reversing low dopamin's effects), thereby reducing your desire to snack out of anxiety. It also helps curb your cravings through an appetite-suppressant effect that helps you feel full for longer periods of time.
Use in Sleep disorders
Naltrexone has been shown to help improve sleeping patterns significantly in patients with sleep apnea.
Naltrexone is contraindicated for known drug allergy and in hepatitis and kidney disorder patients
Naltrexone might harm an unborn baby. There is not enough reliable information about the safety of taking Naltrexone during breast-feeding. Stay on the safe side and avoid use.